Fig.-After the anticoagulant of human heparin was stimulated by PMA/Ionomycin, the control group of the same type was stained with Mouse IgG1 Isotype Control, PE (left peak) and the experimental group with Anti-Human CD69, PE (Clone FN50) (right peak).

Overview of CD69 molecular target information

Molecular name: CD69, CD69 molecule

Gene family: CD molecules; C-type lectin domain containing

Alias: CLEC2C

Full name: CD69 antigen (P60, early t-cell activation antigen)

Review of CD69 molecular targets

CD69 is a type II transmembrane glycoprotein, belonging to the family of C- lectin receptors and a member of the complex family of NK cell signal transduction genes. It is the earliest surface antigen expressed by T lymphocytes after activation. When expressed, it can be used as a co-stimulatory signal to promote the further activation and proliferation of T lymphocytes. CD69 was also induced to express on NK cells, B cells, macrophages, neutrophils and eosinophils. The activated T cells expressing CD69 are mainly CD8+CD 45 RO+,and are mainly induced by IL-15 and related to the contact with activated endothelium expressing ICAM-1. When the exogenous stimulus disappears, the expression of CD69 in activated T cells can decrease rapidly. Therefore, the degree of CD69 expression in lymphocytes after exposure to an antigen can reflect the degree of cell response to the antigen.