Fig.-TF-1 cells were stained with anti-human CD 117, PE (clone: 104d2) (solid line) and Mouse IgG1 κ Isotype Control, PE (dotted line). TF-1 living cells were used for analysis.

Overview of KIT molecular target information

Molecular name: kit, kit proto-oncogene, receptor tyrosine kinase.

Gene family: Receptor tyrosine kinases; CD molecules; Immunoglobulin like domain containing

Alias: CD117; SCFR; C-Kit

Former name: PBT

Full name: mast/stem cell growth factor receptor kit; piebald trait; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Overview of KIT molecular targets

CD117 is also called c-Kit, Steel factor receptor and stem cell factor receptor. This tyrosine kinase protein is mainly expressed in hematopoietic progenitor cells, mast cells and acute myeloid leukemia cells (AML). Activation of CD117 promoted the proliferation and differentiation of these cell subtypes. Lack or deficiency of stem cell factors can lead to a decrease in the number of hematopoietic progenitor cells and severe anemia. CD117 is also expressed by melanocytes and plays a role in signal transduction and activation of these cells.