Figure-Staining human peripheral blood, the picture shows the co-dyeing result of Anti-Human CD127, PE(Clone: 40131) and Anti-Human CD3-APC.

Fig.-The results of Anti-Human CD127, PE (IL-7Rα) and Anti-Human CD3, APC staining in human peripheral blood. The lymphocyte in FSC/SSC was gated for analysis.

Overview of IL7R molecular target information

Molecular name: IL7R, interleukin 7 receptor

Gene family: CD molecules; Fibronectin type III domain containing; Interleukin receptors

Alias: CD127; IL7RA

Review of molecular targets of IL7R

CD127 (IL -7) is a glycoprotein involved in regulating lymphogenesis. The cell response to CD127 depends on the existence of interleukin-7 receptor (IL-7R). CD127 is composed of α chain and γ chain. γ(c) chain is also related to interleukin -2 receptor, which is mainly used to activate the signal transduction of IL-7R complex, while α chain of IL-7R determines specific signal events through its association with cytoplasmic signal molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitor cells and mature CD4+ and CD8+T cells. The biological effect of IL-7 is mediated by the binding of IL-7 to specific cell surface receptors.