Figure-Staining of human peripheral blood, showing the co-staining results of anti-human HLA-DR, APC-CY7 (clone: LN3) and Anti-Human CD3, FITC. Lymphocyte gating was used for analysis.

Overview of molecular target information for HLA-DR

Molecular name: Human Leukocyte Antigen DR

Gene family: DR gene family

Alias: Histocompatibility Antigen-DR, MHC class II molecule

Previously known as: Leukocyte Common Antigen

HLA-DR Molecular Targets Overview

HLA-DR (Human Leukocyte Antigen-DR) is a class II molecule located on human chromosome 6 in the MHC region. It consists of a heterodimer of alpha/beta chains encoded by the DRA and DRB genes, and acts as a core antigen-presenting molecule involved in CD4+ T-cell activation. cell activation. Its high polymorphism affects susceptibility to autoimmune diseases (e.g., rheumatoid arthritis, lupus erythematosus) and serves as a key indicator for transplantation mating.