Overview of p16 molecular target information

Molecular name: p16INK4a

Gene family: INK4 family (Inhibitors of CDK4)

Synonyms: melanoma antigen p16, cell cycle protein-dependent kinase inhibitor 2A Formerly known as: MTS1

p16 Molecular Targets Overview

p16 (also known as p16INK4a or CDKN2A) is a key cell cycle regulatory protein belonging to the INK4 family, which blocks the cell cycle in G1 phase by inhibiting the activity of CDK4/6-cyclin D complex and exerts a tumor suppressor function. Its gene mutation or deletion is closely associated with a variety of cancers (e.g., melanoma, pleural mesothelioma) and aging-related diseases. As a therapeutic target, the regulatory mechanism of p16 is a central site of action for CDK4/6 inhibitors (e.g., Palbociclib) and anti-aging therapies (Senolytics), and is currently being explored for cancer treatment and delayed tissue aging.