Overview of TdT molecular target information

Molecular name: terminal deoxynucleotidyl transferase (TdT)

Gene family: DNA polymerase family X (Pol X family)

Alias: terminal transnucleotidylase

Former name: terminal deoxynucleotidyl transferase

Overview of TdT molecular targets

Terminal deoxynucleotidyl transferase (TdT) is a unique template-free DNA polymerase belonging to the Pol X family of DNA polymerases that is involved in immunodiversity by catalyzing the addition of deoxynucleotides to the 3'-hydroxyl terminus of DNA. hydroxyl terminus of DNA by catalyzing the addition of deoxyribonucleotides to the 3'-hydroxyl terminus of DNA, which is involved in immune diversity formation (e.g., V(D)J recombination) and DNA damage repair. Its core targets include bimetallic catalytic centers (Co²⁺/Mn²⁺ dependent) and conserved motifs (e.g., ALLGW(T/S)GSR), structural domains that confer efficient modification of single/double-stranded DNA ends.