Fig.-The results of anti-human myoperoxidase (MPO)  FITC (clone: MPO 455-8E6) staining on human peripheral blood after membrane rupture.

Overview of MPO molecular target information

Molecular name: MPO, myeloperoxidase

Review of molecular targets of MPO

Myeloperoxidase (MPO) is a peroxidase, which is encoded by MPO gene located on chromosome 17 in humans. It is a lysosomal protein that exists in the eosinophil blue granules of neutrophils and is released into the extracellular space during degranulation. MPO is the most abundant expression in neutrophils, which can produce hypohalous acid with antibacterial activity. MPO has heme pigment, which causes the secretion in neutrophils to appear green, such as pus. In addition, MPO mediates the nitrosation of protein, the formation of 3- chlorotyrosine and the cross-linking of dityrosine. MPO deficiency is a genetic disease that leads to immune deficiency. The increase of MPO level will greatly double the risk of cardiovascular death. Others believe that MPO plays an important role in the development of atherosclerotic lesions and the instability of plaques.