Fig.-results of Daudi cell staining, purple anti-human CD 80 and FITC (clone: 2d10.4), and blue results of isotype control and FITC.

Overview of CD80 molecular target information

Molecular name: CD80, CD80 molecule

Gene family: CD molecules; V-set domain containing; C2-set domain containing; B7 family

Alias: B7.1; B7-1

Former name: CD28LG; CD28LG1

Full name: b-lyric activation antigen B7; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule

Review of CD80 molecular targets

Antigen differentiation cluster 80(CD80) is a protein found in dendritic cells, activated B cells and monocytes, which provides necessary co-stimulation signals for T cell activation and survival. It is also called B7-1. The cDNA of B7-1 is predicted to be a type I membrane protein, which is synthesized on the signal peptide translocated on the endoplasmic membrane. It is predicted that protein contains two extracellular domains, which are similar in structure to Ig, hydrophobic transmembrane domain and short cytoplasmic domain. CD80 and CD86 genes encode B7-1 and B7-2, respectively, which are similar members of immunoglobulin superfamily expressed on various hematopoietic cell types. B7-1 and B7-2 provide costimulatory signals to T cells by interacting with CD28 and CTLA4.