Fig.-results of Anti-Human CD86, PE (Clone:IT2.2) and Anti-Human CD14, APC staining in human peripheral blood. Lymphocytes and monocytes in FSC/SSC were gated for analysis.

Overview of CD86 molecular target information

Molecular names: CD86, CD86 molecule

Gene family: CD molecules; V-set domain containing; B7 family

Alias: B7.2; B7-2

Former name: CD28LG2

Full name: b-lyric antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

Review of molecular targets of CD86

CD86, also known as B7.2, has a molecular weight of 80 kD and is expressed in dendritic cells, monocytes, memory T lymphocytes, germinal center B lymphocytes, activated B lymphocytes and activated T lymphocytes. It belongs to immunoglobulin superfamily, and its ligands are CD28 and CD152 (CTLA4). CD86 interacts with CD28 as inducer and CTLA4 as inhibitor, which is the main synergistic factor to induce T lymphocyte proliferation and produce IL-2.