Fig.-staining of human PBMC induced by antibodies to CD3 and CD28. On the left, the results of Mouse IgG1 Isotype control, APC and Anti-Human CD4, PE are shown, while on the right, the results of Anti-Human CD366, APC(Clone: 1E3) and Anti-Human CD4, PE are shown. All cells are gated.

Overview of HAVCR2 molecular target information

Molecular name: havcr 2, hepatitis a virus cellular receptor 2.

Gene family: V-set domain containing

Alias: Tim-3; TIM3; FLJ14428; TIMD3; CD366

Full name: t-cell immune globulin mucin family member 3

Summary of HAVCR2 molecular targets

TIM3 (hepatitis A virus cell receptor 2, HAVCR2, T cell immunoglobulin) is composed of 281 amino acids, and is a type 1 Th1 specific cell surface glycoprotein, which expresses cells on terminally differentiated CD4+Th1 and CD8+Tc1. TIM3 consists of IgV-like domain, mucin-like domain in extracellular domain and conserved tyrosine phosphorylation motif in cytoplasmic domain. TIM3 participates in the activation of macrophages and the occurrence of autoimmune diseases. In addition, TIM3 mediates immune response and promotes immune tolerance.