Fig.-Anti-Human CD8α, PerCP-Cy5.5 and Mouse IgG1 Isotype Control, PE (left) and Anti-Human CD8α, PerCP-Cy5.5 and Anti-human IL-17a, PE (clone: 64 DEC17) were stained after human heparin anticoagulation was stimulated by PMA/Ionomycin and blocked by BFA/Monensin. The CD3+ cells were used for gated analysis.

Overview of molecular target information of IL17A

Molecular names: IL17A, interleukin 17A

Gene family: Interleukins

Alias: IL-17A; IL-17

Former name: CTLA8; IL17

Full name: cytotoxic t-lympocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

Review of molecular targets of IL-17A

IL-17, which is mainly produced by Th17 cells, is one of more than 30 kinds of interleukins found so far, ranking 17th according to the serial number. The family consists of six member ligands (IL-17A ~ IL-17F) and five receptors (IL-17RA ~ IL-17RD and SEF). IL-17 is an inflammatory cytokine mainly produced by activated T cells, which can promote the activation of T cells and stimulate epithelial cells, endothelial cells and fibroblasts to produce a variety of cytokines, thus leading to inflammation.