Harmful to the human body, excessive lead can be deposited in human tissues, especially bones and renal tubules. Lead salt staining is available in Rose Palm Acid Method and Timm Silver Sulfide Method. Lead salt staining solution (Maipoic acid method) is the use of chelating agent sodium Maipoic acid and lead salts combined to form a red chelate, the staining process should avoid the use of mercury-containing fixative, suitable for paraffin sections.