Most of the aluminum in the body is excreted with feces through the digestive tract, and a small portion accumulates in the testes, kidneys, spleen, muscles, bones and brain tissue. Aluminum accumulation in the brain can cause cerebral nerve degeneration, memory loss, intelligence and personality will also be affected, and even show senile dementia. When the accumulation of aluminum in the body is more than 5-16 times the normal amount, it can inhibit the absorption of phosphorus in the intestine and interfere with the normal calcium and phosphorus metabolism in the body.

Aluminum staining solution (Lillie aluminum reagent method) is based on the principle that the aluminum reagent combines with aluminum ions to produce a red complex, the staining process should avoid the use of mercury-containing fixative, applicable to paraffin sections.