Clone number: UMAB249

isotype: mouse monoclonal antibody

Cellular localization: cell membrane

Tissue: paraffin section

Positive Control:

Antibody incubation time：

Antigen Repair:

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), also known as CD152, is a leukocyte differentiation antigen, a transmembrane receptor on T cells, which shares the ligand for the B7 molecule with CD28, whereas CTLA-4 binds to the B7 molecule and induces T cell unresponsiveness and is involved in the negative regulation of the immune response. Therefore, it plays a role in down-regulating immune response among immune checkpoints and is a target for immunotherapy.

CTLA4 antibody reagents can specifically bind to CTLA4 molecular antigens. Immunohistochemistry kits containing CTLA4 antibody reagents are suitable for predicting the efficacy of immune checkpoint inhibitor therapy (such as ipilimumab) and assessing immune regulatory abnormalities in autoimmune diseases (such as Graves' disease and rheumatoid arthritis).