Clone number: RM175

isotype: rabbit monoclonal antibody

Cellular localization: nucleus

Tissue: paraffin section

Positive control:

Antibody incubation time：

Antigen Repair:

H3K27me3 denotes trimethylation on the 27th amino acid of histone H3. Histone modification plays an important role in tumorigenesis and development, and in recent years, it has been found that a variety of histone modifications are altered in malignant tumors, and that such alterations also have important clinical applications, such as serving as an indicator for determining the prognosis of a patient, a marker for the early diagnosis of tumors, and a judgement as to whether or not a patient can benefit from certain chemotherapeutic agents. 。

The H3K27me3 antibody reagent specifically binds to the H3K27me3 molecular antigen. The immunohistochemistry kit containing the H3K27me3 antibody reagent is suitable for the precise diagnosis of malignant peripheral nerve sheath tumors (MPNST) and certain pediatric gliomas (such as DIPG).