Clone number: MRQ-70

Isotype: rabbit monoclonal antibody IgG

Cellular localization: nucleus

Tissue: paraffin/frozen

Positive control: Pancreas

Antibody incubation time: 30-60min

Antigen repair: Heat repair (EDTA)

The INSM-1 gene is located on chromosome 20p11 and is also known as KLF16. It was first reported in 1992 and is a zinc finger protein with DNA-binding transcriptional regulatory functions. It plays a significant role in neurogenesis and neuroendocrine differentiation and can serve as a broad-spectrum neuroendocrine marker. The sensitivity is comparable to Synaptophysin and CD56, and superior to Chromogranin A.

The INSM-1 antibody reagent can specifically bind to the INSM-1 molecular antigen. The immunohistochemical kit containing the INSM-1 antibody reagent is suitable for the precise diagnosis of carcinoid, lung, head and neck endocrine tumors, primary central nervous system tumors, small cell carcinoma and Merkel cell carcinoma originating from the prostate and cervix.