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MDM2 Antibody Reagent
Wholesale Price(RMB):

102619386161188

Product Code:R-0401202Ⅰ-01/R-0401202Ⅰ-02/R-0401202Ⅱ-01/R-0401202Ⅱ-02
Product model:Type Ⅰ (ready-to-use) / Type Ⅱ (manual ready-to-use)
File Number:
Product Introduction

Clone number: IF2


isotype: mouse monoclonal antibody


Cellular localization: nucleus


Tissue: paraffin/frozen


Positive Control: Liposarcoma


Antibody incubation time: 60min


Antigen repair: Heat repair (EDTA)


Background Information

MDM2 has a molecular weight of 90 kD and forms a complex with p53 protein. p53 and MDM2 are functionally interrelated, with activated p53 leading to the expression of MDM2, which in turn inhibits wild-type p53 from stimulating the expression of its target genes. MDM2 is commonly overexpressed in soft-tissue sarcomas, and to a lesser extent in breast cancers and glioblastomas.


Clinical Value

The MDM2 antibody reagent can specifically bind to the MDM2 antigen. The immunohistochemical kit containing the MDM2 antibody reagent is suitable for the precise diagnosis of liposarcoma.