Clone number: MRQ-69

Isotype: mouse monoclonal antibody IgG

Cellular localization: nucleus

Tissue: paraffin/frozen

Positive control: Rhabdomyosarcoma

Antibody incubation time: 30-60min

Antigen repair: Thermal repair (Tris-EDTA)

PAX-7 plays an important role in myogenesis and early neural development in mammals, especially in self-renewing skeletal muscle tissue. PAX-7 is basically not expressed in normal adult tissues. It only has scattered nuclear expression in skeletal muscle and is not expressed in the smooth muscle and myocardium of internal organs. PAX-7 shows strong nuclear expression in Ewing's sarcoma and rhabdomyosarcoma, especially in the embryonic subtype of rhabdomyosarcoma, while expression is absent in related malignant tumors such as leiomyosarcoma, lymphoblastic lymphoma, neuroblastoma, carcinoid, gastrointestinal stromal tumor and small cell lung cancer. In conclusion, PAX-7 can be used as a marker to assist in differentiating embryonic rhabdomyosarcoma from Ewing's sarcoma.

The PAX-7 antibody reagent can specifically bind to the PAX-7 molecular antigen. The immunohistochemical kit containing the PAX-7 antibody reagent is suitable for the precise diagnosis of embryonal rhabdomyosarcoma and Ewing's sarcoma.