Clone number: UMAB199

isotype: mouse monoclonal antibody

Cellular localization: cytoplasm

reactivity: paraffin/frozen

Positive control: tonsils

Antibody incubation time:

Antigen repair: heat repair (citric acid)

Programmed death factor 1 (PD-1) is expressed in activated T cells, B cells and myeloid cells. Compared to CD10 and Bcl-6, PD-1, a unique marker for angioimmunoblastic T-cell lymphoma, is rarely expressed in B cells, and thus has a higher specificity in the study of angioimmunoblastic lymphoma. In addition, the expression of PD-1 in angioimmunoblast T-cell lymphoma demonstrates its origin from germinal center-associated T cells and indirectly provides support for the tumorigenic progression of such T cells. Such T-cell tumor subtypes may undergo neoplastic transformation, thus leading to their particular histological morphology, immunophenotyping, and clinical subtypes.

PD-1 antibody reagents can specifically bind to PD-1 molecular antigens. Immunohistochemical kits containing PD-1 antibody reagents are suitable for evaluating the immune status of tumor immune microenvironments (such as lymphoma, non-small cell lung cancer) and autoimmune diseases (such as rheumatoid arthritis).