Clone number:

Homozygous:

Cellular localization: cytoplasmic

Tissue: paraffin/frozen

Positive control: Malignant melanoma

Antibody incubation time

Antigen repair/heat repair (citric acid)

PMEL17 is a melanosome-specific antigen, also known as HMB45 or GP100.PMEL17 plays an important role in the developmental maturation of melanocytes from order I to II, the transition of which is characterized by the elongation of vesicles with a well-defined fibrillar internal morphology.PMEL17 is found in immature as well as activated melanocytes (e.g., in inflammatory conditions, proliferating blood vessels, or underlying tumors), but not in mature and resting melanocytes.PMEL17 is also expressed in melanomas. or underlying tumors) and is absent from mature and resting melanocytes.PMEL17 is also expressed in melanomas. Studies have shown that the routine use of PMEL17 can serve as a sensitive and specific melanocyte marker.

The PMEL17 antibody reagent specifically binds to the PMEL17 molecular antigen. The immunohistochemistry kit containing the PMEL17 antibody reagent is suitable for the precise diagnosis of melanoma.