494959330572

494959330572
Clone number: polyclonal
isotype: Rabbit Polyclonal Antibodies
Cellular localization: nucleus
Tissue: paraffin/frozen
Positive control: astrocytes
Antibody incubation time: 30-60min
Antigen repair: Thermal repair (Tri-EDTA)
Alpha thalassemia / mental retardation syndrome X-linked (ATRX) is a deconjugating enzyme that is absent in diffuse astrocytomas but not in hairy cell astrocytomas, and is useful for differentiating hairy cell and diffuse astrocytomas. Astrocytoma is informative.ATRX in combination with IDH-1 mutation and 1p/19q gene status testing (FISH method) is useful for prognostic assessment of patients with high-grade gliomas.
ATRX Antibody Reagent binds specifically to the ATRX molecular antigen, and Immunohistochemistry Kits containing ATRX Antibody Reagent are indicated for the precise diagnosis of hairy cell and diffuse astrocytomas.