Clone number: C-10

Isotype: Mouse Monoclonal Antibodies

Cellular Localization: Nucleus/plasm

Adaptive tissue: paraffin section

Positive Control:

Antibody Incubation Time:

Antigen Repair:

The BCOR gene is localized at Xp11.4 and plays an important role in normal early embryonic development. Expressed in a variety of tumors, such as rhabdomyosarcoma, ossifying fibromucinous tumor subtype (lacking S100 expression), CNS PNET, retinoblastoma, medulloblastoma, hematologic malignancies, renal clear cell sarcoma with BCOR gene abnormality or UWHAE-NUTM2 fusion, and high-grade endometrial mesenchymal stromal tumors with ZC3H7B-BCOR gene fusion Sarcoma. The diagnosis of high-grade endometrial mesenchymal sarcoma with ZC3H7B-BCOR gene fusion is often made in combination with CD10 and CyclinD1.

The BCOR Antibody Reagent binds specifically to BCOR molecular antigens, and the immunohistochemistry kit containing the BCOR Antibody Reagent is suitable for the precise diagnosis of endometrial mesenchymal sarcoma.