Clone number:

Isotype:

Cellular localization: cell membrane

Tissue: paraffin/frozen

Positive control: tonsils

Antibody incubation time: 30-60min

Antigen repair: Heat repair (EDTA)

TROP2 is the trophoblast cell surface protein 2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), belonging to the GA733 protein family. It shares a high degree of structural sequence similarity with epithelial cell adhesion molecule (EpCAM), with homology reaching 49%. TROP2 was initially identified in trophoblast cells and serves as a surface marker, aiding in embryo implantation and placental tissue formation. It also plays a crucial role in maintaining the proliferative properties of embryonic stem cells and in organ development. TROP2 is an important tumor development factor, highly expressed in various tumors such as pancreatic cancer, breast cancer, colorectal cancer, gastric cancer, oral squamous cell carcinoma, and ovarian cancer. It promotes tumor cell proliferation, invasion, and metastasis, and its high expression is closely associated with shorter survival periods and poor prognosis in tumor patients. It is not expressed or is lowly expressed in most normal tissues.  

TROP2 antibody reagents can specifically bind to TROP2 molecular antigens. Immunohistochemistry kits containing TROP2 antibody reagents are suitable for the auxiliary diagnosis of TROP2-high-expressing tumors (such as triple-negative breast cancer, non-small cell lung cancer, and urothelial carcinoma).