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NTRK3 (15q25) gene breakage probe reagent
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501080Ⅰ-01/R-0501080Ⅰ-02/R-0501080Ⅱ-01/R-0501080Ⅱ-02/R-0501080Ⅲ-01/R-0501080Ⅲ-02/R-0501080Ⅳ-01/R-0501080Ⅳ-02
Probe name:GSP NTRK3(Centromere)/ GSP NTRK3(Telomere)
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

Lung Cancer - Non-Small Cell Lung Cancer

NTRK family rearrangements are seen in about 3% of non-small cell lung cancers.LOXO-101 has demonstrated considerable remission rates in the treatment of patients with a wide range of tumors that are fused with NTRK family genes.

Soft Tissue Tumors

NTRK rearrangement spindle cell tumors are rare soft tissue tumors that are molecularly characterized by NTRK rearrangements, with the majority of cases involving NTRK1 gene translocations, and partner genes including LMMA, TMP, TPK, and SOSTM1. A few cases involve NTRK2 and NTRK3 gene translocations, including EML4, STRN, and so on.

Other solid tumors

Targeted therapy: the official website of NMPA shows that NTRK inhibitors larotrectinib and entrectinib were approved and marketed for the treatment of adult and pediatric patients with solid tumors carrying NTRK fusion genes.