The PPARγ gene translocation occurs in 35-47% of patients with follicular thyroid carcinoma; it is seen in 11% of follicular adenomas, 13% of follicular variant PTCs, and 2% of Hurthle cell carcinomas. However, this translocation was not seen in papillary carcinoma, anaplastic thyroid cancer and benign nodular hyperplasia;

Thyroid tumors with the PAX8/PPARγ fusion gene are prone to progression and are considered to be specific oncogenes in the early stages of thyroid follicular carcinoma, which can be used for prognostication;

It is used to detect PPARγ gene breaks and translocations with other genes that are common in thyroid follicular carcinoma.