This probe was applied to the adjuvant diagnosis of fibroplatysmal carcinoma (FL-HCC). Fibrous laminar carcinoma is a rare subtype of hepatocellular carcinoma that occurs mainly in young patients without cirrhosis.The DNAJB1-PRKACA fusion is a characteristic genetic abnormality of fibrous laminar carcinoma, which is accompanied by a deletion of approximately 400 kb in the fusion gene region of chromosome 19.The DNAJB1-PRKACA fusion is seen in all patients with fibrous laminar carcinoma but not in other subtypes (e.g., classic hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, hepatocellular carcinoma, etc.) that need to be differentiated. diagnostic subtypes (e.g., classic hepatocellular carcinoma, cholangiocellular hepatocellular carcinoma, hepatic adenoma, hepatoblastoma).