Renal Tumors

Nephroblastoma (Wilmstumor) is often associated with 1p36 deletion and 1q21-25 acquisition, often in association with 11p deletion (F.01346-01) and 16q deletion (F.01345-01).

Peripheral nerve tissue tumors and tumor-like lesions

deletion is associated with neuroblastoma recurrence, often in association with MYCN (F.01013-01) and KMT2A (11q23) (F.01308-01) gene deletions.

Other solid tumors

Deletion of the 1p36 region (SRD gene) can occur in a variety of tumors such as gliomas/leukemias/lymphomas/neuroblastomas;

In neuroblastomas (the most common extracranial tumors in children) 1p36 is the most typical genetic alteration.

Lymphoma

The 2016 WHO guidelines added the subtype of “1p36-deficient diffuse follicular lymphoma”, grade 1-2, large inguinal mass, limited lesions, CD10/BCL2/BCL6/CD23 positivity with 1p36 deletion, better prognosis.