The 2016 edition of the WHO Classification of Tumors of the Genitourinary Male Genital System added six new kidney tumor types, including hereditary smooth muscle nephroblastoma disease renal cell carcinoma syndrome-associated renal cell carcinoma (HLRCC-RCC), and MiT-family translocated renal cell carcinoma (including Xp11 translocated renal cell carcinoma and t(6;11) translocated renal cell carcinoma);

The t(6;11) translocation results in the formation of a fusion of the MALAT1 and TFEB genes. Morphology is bidirectional, with IHC expression of TFEB, HMB45, MelanA, and cathepsin K. The tumor has an inert biological behavior, with metastasis occurring in only 4 of 50 reported cases;

TFEB translocation renal carcinoma has classical morphological features: pseudochrysanthemum cluster-like structures, two types of cells, basement membrane-like material, grit bodies, pigmentation, etc. t(6;11) renal carcinoma overlaps morphologically with Xp11 RCC, and its morphology can also be similar to that of other renal tumors including clear-cell carcinomas, smoky cell carcinomas, and epithelioid angiomyolipomatosis smooth muscle lipomas.