Urologic Tumors - Clear Cell Papillary Renal Cell Carcinoma

2016 WHO Digestive Tumors has added new subtypes with distinctive cytogenetic abnormalities that aid in diagnosis and differential diagnosis. Acquired Cystic Kidney Disease (ACD)-associated renal cell carcinomas present with abnormalities of chromosomes 3, 7, 16, 17, and Y. Clear cell papillary renal cell carcinoma is a low-grade malignant rare tumor that morphologically needs to be differentiated from a variety of renal carcinomas with clear cell and papillary structures, including clear cell carcinoma, papillary renal cell carcinoma, and Xp11 translocation renal carcinoma. Clear cell papillary renal cell carcinoma does not have the 3p deletion, mutations in the VHL gene, or the acquisition of chromosomes 7 and 17 and the deletion of the Y chromosome that are characteristic of papillary renal carcinoma. In addition, the cytogenetic abnormality in smoky cell renal cell carcinoma is the deletion of chromosomes 1/2/6/10/13/17/21, which can be distinguished from eosinophilic renal cell carcinoma.