Renal Tumors

The development of renal clear cell carcinoma is closely related to the inactivation of the VHL gene on the short arm of chromosome 3, 3p25, and its most notable molecular pathology is characterized by a systemic mutation of the VHL gene, promoter methylation, and deletion of the short arm (3p) of chromosome 3 (70-90% of the cases), which results in the inactivation of the 2 alleles of the gene. This probe contains an internal control #3 filament probe (green) for adjunctive diagnosis of renal clear cell carcinoma;

Multi-atrial cystic renal cell carcinoma was renamed as low malignant potential multi-atrial cystic renal tumors in the 2016 edition of the WHO classification, and immunohistochemistry and molecular pathology were similar to those of renal clear cell carcinomas, which expressed PAX8 and CAIX, and the presence of the VHL mutation and the deletion of 3p in the majority of the tumors (approximately 74%) suggested that they were correlation with clear cell carcinoma at the molecular pathology level. Treatment for this tumor is recommended to be kidney-preserving surgery.

Chromosome number and length

The number of short arms of chromosome 3 was detected.