30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)

30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)
Urologic Tumors - Testicular Genital Tumors
Abnormalities are seen in 67-83% of testicular genitourinary tumors. Abnormalities of the short arm of chromosome 12 (including isochromosomes or amplifications, i12p or +12p) underlie the genetics of post-pubertal testicular GCT, whereas prepubertal testicular GCT and seminomatous tumors lack this molecular abnormality. In addition, molecular testing for i12p or +12p is useful in identifying whether primary somatic cell-type carcinomas (e.g., adenocarcinomas and squamous cell carcinomas, etc.) and sarcomas (rhabdomyosarcomas and embryonal neuroectodermal tumors, etc.) of testicular parenchyma are associated with GCT, and i12p or +12p positivity supports a somatic malignant transformation occurring on the basis of GCT. It can be used as an adjunctive diagnosis for testicular germline tumors.