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12p Probe Reagent
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501155Ⅰ-01/R-0501155Ⅰ-02/R-0501155Ⅱ-01/R-0501155Ⅱ-02/R-0501155Ⅲ-01/R-0501155Ⅲ-02/R-0501155Ⅳ-01/R-0501155Ⅳ-02
Probe name:
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

Urologic Tumors - Testicular Genital Tumors

Abnormalities are seen in 67-83% of testicular genitourinary tumors. Abnormalities of the short arm of chromosome 12 (including isochromosomes or amplifications, i12p or +12p) underlie the genetics of post-pubertal testicular GCT, whereas prepubertal testicular GCT and seminomatous tumors lack this molecular abnormality. In addition, molecular testing for i12p or +12p is useful in identifying whether primary somatic cell-type carcinomas (e.g., adenocarcinomas and squamous cell carcinomas, etc.) and sarcomas (rhabdomyosarcomas and embryonal neuroectodermal tumors, etc.) of testicular parenchyma are associated with GCT, and i12p or +12p positivity supports a somatic malignant transformation occurring on the basis of GCT. It can be used as an adjunctive diagnosis for testicular germline tumors.