Multiple myeloma (MM)

1q21 (CKS1B) is the most common genetic abnormality in MM, and amplification of the CKS1B gene leads to upregulation of cell cycle cycling, which causes many proliferative disorders;

1q21 amplification is often associated with an infiltrative phenotype in MM, with a poor prognosis and rapid progression of the disease;

Deletion of 1p32-36 can be seen in 16% of MM, and deletion of this region leads to loss of tumor suppressor genes, resulting in the Proliferative disease;

This probe combination detects 1p36 deletion and 1q21 region amplification.

Chromosome number and long and short arm detection

1q21 amplification is often associated with an infiltrative phenotype in MM, with poor prognosis and rapid disease progression; deletions of 1p32-36 can occur in 16% of MM, leading to the development of proliferative disease.