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E2A (19p13) gene breakage probe reagent
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501229Ⅰ-01/R-0501229Ⅰ-02/R-0501229Ⅱ-01/R-0501229Ⅱ-02/R-0501229Ⅲ-01/R-0501229Ⅲ-02/R-0501229Ⅳ-01/R-0501229Ⅳ-02
Probe name:GSP E2A(Centromere)/ GSP E2A(Telomere)
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

The E2A gene can be fused to the PBX1 and HLF genes; E2A/PBX1 is more common (5%), while E2A/HLF is less common (1%);


It accounts for about 5% of childhood ALL; both fusions imply a poor prognosis and a high risk of recurrence;


Karyotyping tends to lead to 20-25% missed diagnoses, a shortcoming that can be overcome by FISH;


These patients often relapse early after standard chemotherapy.