Fibroblastic/myofibroblastic tumors and tumor-like lesions

Applied to low-grade fibromyxoidsarcoma (low-grade fibromyxoid sarcoma);

Low-grade malignant fibromyxoid sarcoma with well-defined curved vascularized, mucinous areas, accompanied by megacollagenous chrysanthemum masses in some cases; immunohistochemistry positive for MUC4, a sensitive and specific marker;

95% of low-grade malignant fibromyxoid sarcomas present with a Characteristic FUS/CREB3L2 gene fusion (t(7;16)(q34;p11)), which can also be found in hybrid tumors with features of both LGFMS and sclerosing epithelioid fibrosarcoma, whereas this gene fusion is not detected in other fibrous or mucinous tumors.

Fibrous Histiocytic Tumors and Neoplastic Lesions

The FUS gene breakage probe detects whether breaks and translocations of the FUS gene occur, for example:

FUS undergoes t(12;16)(q13;p11) reciprocal translocation in mucinous liposarcoma; reciprocal translocation with the ERG gene in AML; reciprocal translocation with the ATF1 gene in hemangiomatoid fibrous histiocytoma; and reciprocal translocation with CREB3L2 in mucinous fibrosarcoma;

Mucinous fibrosarcoma is a malignant fibroblastic tumor with varying degrees of mucinous stroma, tumor cell pleomorphism, and prominent curved blood vessels. It was formerly known as mucinous malignant fibrous histiocytoma. It is one of the most common sarcomas in the elderly, with an age of onset of 60-80 years, and is extremely rare below the age of 20 years. It is mainly distinguished from low-grade malignant fibromucinous sarcoma, mucinous liposarcoma, mucinous neurofibroma, mucocele, or superficial angio-mucinous tumor;

Low-grade malignant fibromucinous sarcoma is rare and is also known as vitellogenic spindle cell tumor with giant chrysomelic masses. Prevalent in young and middle-aged adults with a median age of 34 years. Mainly differentiated from isolated fibrous tumor; mucinous fibrosarcoma. The tumor has a characteristic FUS-CREB3L2 or FUS-CREB3L gene fusion;

May be used as an aid in the diagnosis of soft tissue tumors including mucinous liposarcoma, mucinous fibrosarcoma, hemangiomatoid fibrous histiocytoma, low-grade malignant fibromucinous sarcoma,acute myeloid leukemia.