Acute myeloid leukemia (AML)

KMT2A (MLL) is located at 11q23, a region of common chromosomal abnormalities, including translocation insertions and deletions;

KMT2A gene abnormalities are seen in ML and LL, with an incidence of up to 85% in childhood B-ALL, and also in lymphomas; prognosis is poor, with a high risk of therapeutic failure;

Simple KMT2A breaks in AML suggest a prognosis of Moderate.

Acute lymphoblastic leukemia (ALL)

KMT2A (MLL) gene is located at 11q23, a region of common chromosomal abnormalities, including translocation insertions and deletions;

KMT2A gene abnormalities are seen in ML and LL, with up to an 85% prevalence in childhood B-ALL, and also in lymphoma; poor prognosis and high risk of treatment failure;

is a marker of ALL with the worst prognosis.