30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)

30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)
t(4;11) (q21;q23) KMT2A (MLL)/AFF1 is the most common KMT2A-related translocation in ALL;
The KMT2A /AFF1 fusion protein is involved in hematopoietic stem cell self-renewal/differentiation, and high expression causes poor prognosis;
ALL patients with KMT2A /AFF1 fusion are at high risk of treatment failure.