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CRLF2 (Xp22 Yp11) gene breakage probe
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501336Ⅰ-01/R-0501336Ⅰ-02/R-0501336Ⅱ-01/R-0501336Ⅱ-02/R-0501336Ⅲ-01/R-0501336Ⅲ-02/R-0501336Ⅳ-01/R-0501336Ⅳ-02
Probe name:GSP CRLF2(Centromere)/ GSP CRLF2(Telomere)
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

BCR-ABL1-like ALL (Ph-like ALL) is associated with a poor prognosis (5-year DFS of 60%) and is less common in pediatric B-cell ALL (3%) but is the most common subtype in adult ALL (25%); the


Ph-like ALL incidence is positively correlated with increasing age.


Abnormal kinase activation (ABL1, EPOR, JAK2, PDGFRB, EBF1, FLT2, IL7R, and SH2B3) is seen in 90% of Ph-like ALL and may be amenable to ABL1 TKI therapy.


CRLF2 gene rearrangement occurs in 50% of cases in Ph-like ALL and is associated with poor prognosis.