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PD-L1(9p24)/ABL1(9q34) Gene Amplification Probe Reagent
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501377Ⅰ-01/R-0501377Ⅰ-02/R-0501377Ⅱ-01/R-0501377Ⅱ-02/R-0501377Ⅲ-01/R-0501377Ⅲ-02/R-0501377Ⅳ-01/R-0501377Ⅳ-02
Probe name:GSP PD-L1 / GSP ABL1
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

A recurrent genetic abnormality in nodular sclerosing Hodgkin's lymphoma when the 9p24.1 region is amplified. And the PD-L1 and PD-L2 genes encoding PD-1 ligand proteins (also known as CD274 and PDCD1LG2, respectively) on this segment are important target genes in the 9p24.1 segment;


Hodgkin's lymphoma data published in JCO in 2016 showed that out of 108 cases, 2 were 9p24.1 diploid, 5 were polymorphic (Polysomy), 61 were gained (Copygain), 39 were amplified (Amplification), and 2 were translocated (Translocation);


The internal reference gene for this probe is the non-nodule probe ABL1 (9q34).