The papillary glial neuronal tumor class of tumors of neuronal and mixed neuronal-glial origin in the 2021 edition of the CNS classification is accompanied by an SLC44A1-PRKCA gene fusion, which can be designed to be detected by a PRKCA break FISH probe.

Note: Chordoid gliomas have relatively unique clinical and pathohistological features, and the vast majority of cases are accompanied by the characteristic D463H mutation in the PRKCA gene, which can be considered as a reference for the diagnosis and differential diagnosis of chordoid gliomas without PRKCA fusion.