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p53 deletion/D13S319 deletion probe, 1q21 amplification probe (single red), MAF/IGH fusion probe, FGFR3/IGH fusion probe reagents
Wholesale Price(RMB):

1200024000132002640013200264001440028800

Product Code:R-0501419Ⅰ-01/R-0501419Ⅰ-02/R-0501419Ⅱ-01/R-0501419Ⅱ-02/R-0501419Ⅲ-01/R-0501419Ⅲ-02/R-0501419Ⅳ-01/R-0501419Ⅳ-02
Probe name:Hybridization solution I: GSP p53 / GSP D13S319; Hybridization solution II: GSP 1q21; Hybridization solution III: GSP IGH / GSP MAF; Hybridization solution IV: GSP IGH / GSP FGFR3
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

Application to the diagnosis and prognostic stratification of multiple myeloma. Two fusion genes, [MAF/IGH]/[FGFR3/IGH], were introduced on the basis of [D13S319/p53]/1q21, and if the IGH translocation was positive, the two translocations, t(14;16) [MAF/IGH] and t(4;14) [FGFR3/IGH], were detected together. These two translocations are associated with poor prognosis; and t(4;14) [FGFR3/IGH] is not detected by conventional karyotyping. This product combines diagnostic and prognostic stratification in a single product that includes a diagnostic package for primary screening and, most importantly, a fusion probe for prognostic stratification.