CD1a Molecular Target Information Overview

Molecular Name: CD1a molecule

Gene Family: The CD1 family, which is structurally similar to the major histocompatibility complex (MHC) proteins, is responsible for the presentation of lipid or glycolipid antigens.

Synonyms: CD1A, R4, T6, FCB6, HTA1, T-cell surface glycoprotein CD1a, CD antigen CD1a

Formerly known as: T-cell surface antigen T6/Leu-6

CD1a molecular targets overview

Molecular weight is 49 kD, and is expressed on thymocytes in 60% to 90% expression on thymocytes. Also expressed on dendritic cells, Langerhans cells, monocytes activated by GM-CSF alone or in combination with IL-4, certain T-lymphoblastic leukemia and lymphoma cells, and dendritic cells of the skin. It does not cross-react with peripheral blood T-lymphocytes, B-lymphocytes, monocytes, normal bone marrow monocytes, or normal tonsillar T- and B-lymphocytes. It belongs to the immunoglobulin superfamily and has a molecular structure similar to that of MHC class I molecules.

CD1a can be used to detect immunophenotyping of cutaneous Langerhans cells, T-lymphoblastic leukemias and lymphomas, as well as for the study of T-lymphocyte expression in the case of immune system dysfunction due to immunodeficiency.