Figure - Human peripheral blood staining with Mouse IgG1 Isotype control, PE on the left and results of Anti-Human CD11b,PE (Clone: LT11) on the right. Lymphocytes, granulocytes and monocytes were used as gates for analysis.

Overview of ITGAM Molecular Target Information

Molecular name: ITGAM, integrin αM subunit

Gene family: complement molecule; integrin α subunit; regulator and receptor of the complement system

Alias: MAC-1; CD11b

Formerly known as: CR3A; CD11B

Full name: Complement Component 3 Receptor 3 subunit; Macrophage-1 antigen α subunit; Integrin, αM (Complement Component Receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide); integrin, αM (complement component 3 receptor 3 subunit)

Overview of ITGAM Molecular Targets

Integrin αM (ITGAM) is a subunit of a protein that forms either macrophage antigen (Mac-1) or complement receptor 3 (CR3).ITGAM is also known as CR3A and differentiation antigen cluster molecule 11B (CD11b).CD11b is a common myeloid marker with a 50% positive expression rate in acute myeloid leukemia.Combined detection of CD117 and CD11b is useful in differentiating acute promyelocytic leukemia (CD11b-negative expression) from cases with resumption of benign proliferation (CD117-negative expression, CD11b-positive expression).