Figure - Results of human peripheral blood staining for Anti-Human CD11c, APC (Clone:3.9) and Anti-Human CD14, FITC. Lymphocytes and monocytes from FSC/SSC were used as gates for analysis.

Overview of ITGAX Molecular Target Information

Molecular Name: ITGAX, integrin αX subunit

Gene Family: CD Molecule; Integrin α subunit; Complement System Regulator and Receptor

Alias: CD11c

Formerly known as: CD11C

Full name: Complement Component 3 Receptor 4 subunit; Integrin, αX (antigen CD11C (p150), α polypeptide); Integrin, αX (Complement Component 3 receptor 4 subunit)

ITGAX Overview of molecular targets

CD11c, known as complement receptor 4 (CR4), is a member of the CD11/CD18 family of adhesion molecules, which belong to type I transmembrane glycoproteins and are highly expressed on the surface of myeloid DCs.CD11c serves as a positive regulator involved in the adhesion and migration of DCs, antigen recognition and presentation, and activation of CD4+ and CD8+ T cells, regulating the occurrence of immune response and playing an important role in infection and anti-tumor immunity.