Figure - Results of human peripheral blood staining for Anti-Human CD13, PE (Clone: WM15) (solid line) and Mouse IgG1 κ Isotype Control, PE (dashed line). Granulocytes in FSC/SSC were used as gates for analysis.

Overview of molecular target information for ANPEP

Molecular name: ANPEP, alanyl aminopeptidase, membrane

Gene family: aminopeptidases; CD molecules; M1 metallopeptidases

Synonyms: LAP1; gp150; p150

Formerly known as: CD13 ; PEPN

Full name: aminopeptidase N; aminopeptidase M; microsomal aminopeptidase; membrane alanyl aminopeptidase; alanyl (membrane) aminopeptidase

ANPEP Molecular Targets Review

CD13, also known as amino acid peptide N, is a member of the metalloproteinase membrane integrin type II. CD13 is a receptor for coronaviruses, which cause respiratory disease in humans and several animal species. CD13 functions as a zinc-binding metalloproteinase that modifies the N-terminal amino acids in the expression of cell-surface antigens through MHC class II binding peptides. CD13 is expressed in granulocytes, monocytes and their precursor cells, as well as in most acute myeloid leukemias and a small proportion of acute lymphoblastic leukemias. In non-hematopoietic cells, CD13 is expressed in epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoblasts, and bile duct lining cells.