CD41 Molecular Target Information Overview

Molecular name: Integrin alphaIIb (Integrin alpha-IIb), full name Integrin alpha2b (Platelet Glycoprotein IIb, component of the IIb/IIIa complex)

Gene family: Integrin family ( Integrin family), belongs to the transmembrane glycoprotein receptor superfamily

AKA: gpIIb, CD41, ITGA2B (gene symbol), Platelet Glycoprotein IIb (Glycoprotein IIb)

Formerly known as: T-cell Surface Antigen TSPAN-29, alpha subunit of the IIb/IIIa complex

A review of the molecular targets of CD41

AKA for Glycoprotein Iib (GPIIb) or integrin αIIb chain, is a heterodimer of GPIIbb, with a molecular weight of 125 kD for GPIIa and 22 kD for GPIIb, expressed on platelets and megakaryocytes. It belongs to the integrin α subunit family. CD41 binds to GPIIIa (CD61) to form a receptor for platelet fibrinogen, which regulates platelet aggregation. ligands and related molecules of CD41/CD61 include fibronectin, fibrinogen, fibrinogen, thrombospondin, TSP, vitronectin, and vascular hemophilic factor.

It is used clinically for the diagnosis of Glanzmann-type platelet akinesia (hereditary GPIIb/IIIa deficiency), and for the immunophenotyping and diagnosis of pro-macrocytic/megakaryocytic leukemia cells (acute myeloid leukemia type M7).