Figure - Results of human peripheral blood staining for Anti-Human CD45, mFluor 610 (Clone:HI30). Analyzed with human peripheral blood cells.

Figure - Results of human peripheral blood staining for Anti-Human CD45, mFluor 610 (Clone:2D1). Human peripheral blood cells were used for analysis.

PTPRC Molecular Target Information Overview

Molecular Name: PTPRC, protein tyrosine phosphatase receptor type C

Gene Family: CD molecules; Fibronectin type III domain containing; Protein tyrosine phosphatases receptor type

Synonyms: LCA; T200; GP180

Formerly known as: CD45

PTPRC Molecular Targets Overview

CD45, also known as leukocyte common antigen (LCA), consists of a class of structurally similar, high molecular weight (180 kDa, 190 kDa, 205 kDa, 205 kDa, 205 kDa, 205 kDa, 205 kDa) molecules. LCA consists of a group of structurally similar transmembrane proteins with large molecular weights (180 kDa, 190 kDa, 205 kDa, and 200 kDa), which are widely present on the surface of all leukocytes (including lymphocytes, granulocytes, and monocytes) but are not expressed on mature erythrocytes, platelets, mature red lineage cells in bone marrow, or in nonhematopoietic tissues.The cytoplasmic compartment of CD45 acts as a protein tyrosine phosphatase and activates tyrosine dephosphorylation on the substrates P56lck and P59fyn. The cytoplasmic region of CD45 has the function of a protein tyrosine phosphatase, which can activate the substrate P56lck and P59fyn by dephosphorylating tyrosine and play an important role in cellular information transmission.CD45 is a key molecule of signaling on the cell membrane, and is of great significance in the development and maturation of lymphocytes and in the regulation of their functions as well as in the transmission of signals.CD45 distribution may be used as a marker for the classification of certain T-cell subsets.