Figure - Results of human peripheral blood staining for Anti-Human CD45RA, FITC (Clone:HI100) and Anti-Human CD45RO, PE. Lymphocytes in FSC/SSC were used as a gate for analysis.

Overview of CD45RA molecular target information

Molecular Name: Protein Tyrosine Phosphatase Receptor Type C Isoform CD45RA

Gene Family: Protein Tyrosine Phosphatase (PTP) Family

Synonyms: GP180, L-CA (Leukocyte Common Antigen), LCA, LY5, T200, PTPRC, B220

Formerly known as: CD45 Isoform, Leukocyte Common Antigen RA form

Overview of the molecular targets of CD45RA

Molecular weight is 205/220 kD and is expressed on naïve/resting T lymphocytes, B lymphocytes, granulocytes and monocytes. It belongs to the PTPase receptor family and its ligand is CD22.

CD45RA has tyrosine phosphatase activity and regulates signaling through the TCR. In T-lymphocytes CD45RA+ and CD45RO- cells are unactivated T-lymphocytes, which are comparable to suppressor T-lymphocytes, and activation of unactivated T-lymphocytes results in a decrease in CD45RA and an increase in CD45RO and CD29.

CD45RA is used in the diagnosis of lymphoma and also in the differentiation of cancer cells and sarcoma cells.