Overview of CD57 molecular target information

Molecular Name: HNK-1 Carbohydrate Epitope

Gene Family: Glycosyltransferase Family

Synonyms: HNK-1, LEU7, NCAM1 Related Carbohydrate Epitope

Formerly: CD57 Antigen, B3GAT1 Enzyme Product

CD57 Molecular Targets Overview

Molecular weight is 110 kD and is expressed on NK cells, T-lymphocyte subtypes, B-lymphocytes and monocytes. It is a carbohydrate molecule that is a component of several glycoproteins.

CD57 is expressed on B-CLL, malignant melanoma, small cell lung cancer, and fetal neuroepithelial cells. CD57 glycan chains in the brain are bound to neuronal cell adhesion molecules, myelin-associated glycoprotein (MAG), lipids, etc. CD57+ T lymphocytes are increased after AIDS and organ transplantation.