Overview of CD58 molecular target information

Molecular name: Lymphocyte function-associated antigen 3, LFA-3

Gene family: Immunoglobulin Superfamily (IgSF)

Synonyms: LFA-3, Ag3, Surface glycoprotein LFA-3 , GP180

Formerly known as: P55/P70

CD58 Molecular Targets Overview

The molecular weight of CD58 is 45-70 kD, and it is expressed on a wide variety of hematopoietic and non-hematopoietic cells, including leukocytes, endothelial cells, epithelial cells, and fibroblasts. It belongs to the immunoglobulin superfamily and is one of the CD2/CD48/CD58 class of molecules whose ligand is CD2 (LFA-2).

CD58 is a single-chain glycoprotein with two types, type I membrane penetrating and GPI-binding. GPI-bound CD58 is found on almost all cells in the organism.

The amino terminus of CD58 binds to the amino terminus of CD2 for cell adhesion reactions. It is important for antigen-specific activation of T lymphocytes and T lymphocyte-dependent cytolysis, and is involved in adhesion reactions between killer T lymphocytes and target cells, antigen-presenting cells and T lymphocytes, and thymocytes and thymic epithelial cells, providing co-stimulatory signals.