Clone number:

Homozygous:

Cellular localization: nucleus

Adaptive tissue: paraffin/frozen

Positive control: tonsils

Antibody incubation time: 30-60min

Antigen repair: Heat repair (EDTA)

PU.1, as a transcription factor belonging to the Ets protein family, plays a crucial role in the development of normal B cells. It is expressed in bone marrow cell lines and B cells but not in plasma cells. PU.1 is essential for the early differentiation of B cells, and its absence causes B cell development to arrest at the early stage. PU.1 is expressed in germinal center and mantle zone B cells, as well as in various lymphomas, including: chronic B-cell leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, and nodular lymphocytic Hodgkin lymphoma. Torlakovic et al.'s research indicates that high expression of germinal center antigens (including PU.1) in follicular lymphoma is positively correlated with overall survival and progression-free survival in a quantifiable manner.

PU.1 antibody reagents can specifically bind to PU.1 molecular antigens. Immunohistochemistry kits containing PU.1 antibody reagents are suitable for the auxiliary diagnosis of acute myeloid leukemia/AML, lymphoma, and other diseases.